The Myocardium

HYPOVENTILATION PRIOR TO ISCHEMIA PRECONDITIONS RAT MYOCARDIUM

Repetitive episodes of brief regional ischemia have been shown to reduce the severity of life-threatening ventricular anhythrnias and infarct size that occur during prolonged occlusion of the coronary artery. This phenomenon is known as ischemic preconditioning. During studies in anesthetized, open chest Wistar rats, we accidentally observed that poorly ventilated animals had a reduced seve...

Integrins and the myocardium.

Extracellular matrix provides a structural, chemical, and mechanical substrate that is essential in cardiac development, growth, and responses to pathophysiological signals. Transmembrane receptors termed integrins provide a dynamic interaction of environmental cues and intracellular events. Integrins orchestrate multiple functions in the intact organism including organogenesis, regulation of g...

Patching up the myocardium.

Cell therapy, while retaining promise for cardiac regeneration, has thus far been encumbered by variable and unpredictable fates of delivered cells. In a recent issue of PNAS, Godier-Furnémont and colleagues describe a new strategy to regulate cell delivery by promoting specific migration and growth factor secretion behaviors of implanted cells from a decellularized matrix via biochemical preco...

Tuberculoma of the Myocardium

(DMO) from the myocardium

1. The efflux of IT-labelled 5,5-dimethyl-2,4oxazolidinedione (DMO) from the myocardium of the rabbit has been studied. The perfusate pH was 7.38. 2. The effluent curve is complex and appears to be the resultant of movement between at least four compartments. 3. The first two probably represent intravascular and extracellular compartments; the last two have smaller rate constants and may repres...